Strategic guidance for technical founders in biotech

Hey {{first_name|default:there}}, it’s Vadim 👋

I'm incredibly excited to kick off something I've been working on for a while: the 6-Week Investor Sourcing Intensive.

Over the next month and a half, we're going to build your dream investor list together - systematically, strategically, and ready to activate in Q1.

Why I'm doing this:

I've watched too many brilliant founders waste months (and in some cases, years) pitching zombie funds, investors who don't do biotech, and people who will never write a check.

Finding the right investors is exponentially harder in biotech than any other industry. Your market is fragmented. Your timelines are longer. Your science is complex. The "Top 100 VC" lists floating around LinkedIn? Useless for pre-seed biotech founders.

Today, I want to change that. This intensive is designed to take you from scattered and reactive to an intentional and strategic fundraise.

Why now:

Q1 is when you want to be fundraise-ready. JPM happens in January. Investors are back from holidays with fresh budgets and renewed focus. If you want to hit the ground running in Q1 2026, December is when you build your list - not when you start pitching.

Here's what we're covering:

🧭 Week 1 (Today): The SIFT System - your complete investor intelligence framework

🧭 Week 2: Angels & Angel Groups - finding biotech-savvy angels who write $25K-$500K checks

🧭 Week 3: Family Offices - demystifying the most opaque capital source in biotech

🧭 Week 4: Micro-VCs - the $2M-50M funds perfect for pre-seed (and how to find them)

🧭 Week 5: Established VCs - understanding fund hierarchy and when to target mid-size vs mega-funds

🧭 Week 6: Putting it all together - databases, AI tools, qualification process, your final 200-300 targets

By December 31st, you'll have a qualified, tiered, strategic investor list ready to go. No more guessing. No more wasted meetings. Just a clear roadmap.

Let's get started.

FOUNDER STORY

The mistakes you learn from are often the most expensive ones

I have to be honest with you about something.

The first time I helped a friend raise funding, it was a complete disaster. We made every mistake in the book… and I do mean every mistake.

Taking random meetings with someone's high-net-worth uncle who had never invested as an angel (and gave no indication he would)? Check.

Meeting with a "Ventures" group only to discover they were actually a consulting firm looking for our business? Check.

Paying several thousand dollars for a "MASSIVE" investor database, only to find it was scraped from Crunchbase, had the front desk receptionist's email as contact info, and was full of funds that never invested in biotech? Expensive check.

Spending months in meetings and even going into due diligence with a fund, only to discover they had no capital to deploy and were still doing their own fundraising? Incredibly frustrating check.

We were scattered. Reactive. Chasing every intro, responding to every LinkedIn message, taking every meeting offered. We thought we were being aggressive and opportunistic.

We were actually just wasting our most precious resource - time - during the most precious time for a company: the very beginning, when speed and momentum are everything.

This experience left scars. But it also taught me something critical: the problem wasn't our pitch, our science, or our business model. The problem was our list and our approach.

I see this pattern repeat constantly with other founders. Brilliant scientists spending month after month pitching zombie funds, investors who don't do biotech, or people who will never write a check.

Helping founders avoid this became the founding ethos for Bio Founder GPS. It's my mission with everything I do behind this newsletter.

My goal is simple: help you go from scattered and reactive to intentional and strategic.

Today is the first step. Let's build your investor intelligence system - the right way.

FRAMEWORK

The SIFT System: Your investor intelligence framework

Here's what I learned from that painful experience: going from scattered to strategic doesn't start with perfecting your pitch deck or practicing your elevator speech.

It starts with how you source.

Most founders skip straight to outreach with whatever list they can cobble together - maybe 50 names from a "Top VCs in Biotech" blog post, a few intros from advisors, and whoever responded to their cold LinkedIn messages.

That's backwards.

Here's the reality: You need 100+ investor meetings to raise a round. If 20-30% of your outreach converts to meetings (and that's very optimistic), you need to contact 300-500 qualified investors - at a minimum. Which means your initial universe needs to be even bigger.

The SIFT System gives you that list systematically.

Here's how it works:

SIFT = Source → Isolate → Filter → Tier

  1. Source (500-1,500) - Build your comprehensive universe from all available channels

  2. Isolate (300-500) - Extract biotech-relevant investors by sector, stage, and geography

  3. Filter (200-300) - Remove inactive funds and validate actual deployment

  4. Tier (Final 200-300) - Rank by strategic value into prioritized outreach lists

It's designed to take you from a scattered, reactive approach to an intentional, strategic fundraise. Four clear steps with specific outputs at each stage. And by the end, you'll have 200-300 investors ranked by priority, all actively deploying capital in biotech.

Let me walk you through each step in detail.

Step 1: SOURCE (500-1,500 investor names)

Goal: Cast the widest possible net to build your complete investor universe.

What you're doing: Systematically collecting investor names from every available source - free databases, LinkedIn, Twitter, portfolio company research, conference lists, accelerator networks, everywhere.

Note, this is a 5-week process, not a 1-week sprint:

You'll start with broad sourcing this week (Week 1), then learn specialized tactics for each investor type in Weeks 2-5. Angels require different sourcing strategies than family offices. Micro-VCs hide in different places than established VCs.

Week 1 focus: Set up your tracking system and build your foundation (200-300 names) using:

  • Crunchbase searches (via a free trial)

  • LinkedIn broad searches

  • Comparable company research (10-15 companies like yours)

  • Twitter/X investor lists

Weeks 2-5 focus: Each week you'll learn expert tactics for one investor type and add 50-150+ specialized names.

Why this matters: Most founders use the same generic searches for all investor types and miss 70% of the opportunities. We're doing this methodically - one category at a time, with specialized strategies.

Mindset shift: You're not building your complete list this week, you're building the foundation and learning the system. Each of the next 4 weeks will teach you specialized tactics to expand this list further.

Output: A spreadsheet with 200-300 investor names and the infrastructure to add hundreds more over the coming weeks.

Step 2: ISOLATE (300-500 biotech-relevant investors)

Goal: Extract only the investors who are actually relevant to biotech companies at your stage.

What you're doing: Applying surgical filters to remove everyone who shouldn't be on your list. This is where you get specific.

Key filters to apply:

Filter 1: Biotech/Life Science Focus

  • Not just "healthcare" - you need investors with actual biotech portfolio companies

  • Look for: therapeutics, diagnostics, medical devices, platform technologies in their portfolio

  • Red flag: All their investments are in digital health, telehealth, or health insurance tech

Filter 2: Stage Match

  • Are they actually writing checks at pre-seed or seed?

  • Many "early-stage" VCs haven't done a pre-seed deal in 3 years

  • Look at their last 10 deals - what stages were they?

Filter 3: Geography

  • Will they invest in your region, or are they hyper-local?

  • Some funds have a region or state focus

  • International founders: Check if US funds invest outside the US

Filter 4: Check Size

  • Do their typical investments match your raise?

  • If you're raising $500k and they write $5M+ checks, you're wasting your time

  • If you're raising $5M and they write $50K checks, also likely a mismatch

Mindset shift: This is where you go from "any investor" to "investors who could plausibly fund a company like mine." Every name that survives this step should have biotech DNA and stage alignment.

How to research efficiently:

  • Check their website portfolio page

  • Look up their last 5-10 deals on Crunchbase

  • Read their "investment criteria" or "what we look for" pages

  • If you can't confirm biotech focus + stage fit, take them off your list

Output: 200-300 investors who have the profile to invest in your company. Still no outreach. We're not done qualifying yet.

Step 3: FILTER (200-300 active deployers)

Goal: Eliminate zombie funds and identify investors who are actively writing checks right now.

What you're doing: Validating actual deployment activity. This is the step most founders skip, and it's why they waste months on dead-end conversations.

Here's the hard truth: 30-40% of the investors on your list are zombies. They'll take meetings. They'll ask for your deck. They'll even give you feedback. But they're not deploying capital.

How to identify active deployers:

Signal 1: Last deal date

  • When was their most recent investment?

  • Active = deals in the last 12-18 months

  • Zombie = no deals in 18+ months, but still "taking meetings"

Signal 2: Fund vintage

  • What year did they close their current fund?

  • Sweet spot = Years 1-4 of a fund's life (most active deployment)

  • Caution = Year 5+ (often reserved for follow-ons, not new deals)

Signal 3: Deployment velocity

  • How many deals do they do per year?

  • A fund doing 2-3 deals/year has limited slots

  • A fund doing 20+ deals/year has more opportunities

Signal 4: Team status

  • Is the biotech-focused partner still there?

  • Did the life sciences team leave to start their own fund?

  • Personnel changes can make a "biotech fund" inactive in that sector

Signal 5: Fund status

  • Are they currently fundraising for their next fund?

  • Funds in fundraising mode often slow or pause investments

Zombie fund red flags:

  • "We're always taking meetings" (but no deals in 18 months)

  • "Send us your deck and we'll take a look" (vague timeline)

  • "We love the space" (but zero biotech deals in portfolio)

  • "Let's stay in touch" after every meeting (perpetual interest, no action)

Where to check:

  • Crunchbase: Filter investments by date

  • Their website: News/press releases section

  • LinkedIn: Search "[Fund Name] + investment"

  • Newsletters: BioCentury, Endpoints News, FierceBiotech deal coverage

Mindset shift: An interested conversation with a zombie fund is worse than a "no" from an active fund. It consumes time, creates false momentum, and delays your actual fundraise. Cut them ruthlessly.

Output: 100-150 investors who are actively deploying capital in biotech right now. These are real opportunities, not time sinks.

Step 4: TIER (Final 200-300 strategically ranked)

Goal: Prioritize by strategic value and likelihood to create your final, tiered outreach list.

What you're doing: Not all active, biotech-focused investors are created equal. Some bring strategic value beyond the check. Some are more likely to say yes based on your network. This is where you rank them.

How to create your tiers:

Tier 1: Dream Investors (50 names) These are your highest-priority targets. Perfect fit + strategic value + reasonable path to introduction.

Characteristics:

  • Portfolio companies in your exact space (competitive intelligence value)

  • Strong network in pharma/biotech (BD intro potential)

  • Follow-on capital available (can support through Series A/B)

  • Reputation adds credibility (helps with next round)

  • Warm intro is possible (mutual connection, advisor, portfolio founder)

Tier 2: Likely Yes (100 names) Strong fit + active deployment + decent access path.

Characteristics:

  • Clear biotech focus and stage match

  • Recent similar investments

  • Reasonable path in (cold outreach with good targeting could work)

  • May not have all strategic bells and whistles, but solid partners

Tier 3: Backup Targets (100 names) Decent fit + worth a shot if Tier 1/2 don't convert.

Characteristics:

  • Biotech-adjacent or sector-flexible

  • Active but less frequent deployers

  • Newer funds or emerging managers

  • Long-shot warm intros

  • Geographic stretch but possible

How to score strategic value:

Ask yourself:

  • Do they have portfolio companies I can learn from or partner with?

  • Can they make meaningful pharma or customer introductions?

  • Do they have deep scientific expertise to help with R&D decisions?

  • Will their name on my cap table help with the next round?

  • Can they provide follow-on capital, or will I need to re-raise in 12 months?

Access path considerations:

  • Direct warm intro = Tier 1 (if other factors align)

  • Second-degree connection = Tier 1 or 2

  • Cold outreach required = Tier 2 or 3

  • No clear path = Tier 3

Mindset shift: You're not just finding investors, you're finding partners. The best investor isn't always the one who can write the biggest check. It's the one who can help you build a better company.

Output: Your final 200-300 investors, organized into three tiers. This is your fundraising roadmap. Tier 1 gets first outreach. Tier 2 follows. Tier 3 is your safety net.

YOUR ACTION PLAN

Your 30-day sprint starts now: Week 1 foundation

This week's goal: Set up your infrastructure and build your foundation list (200-300 names)

Time commitment: 6-8 hours total

Important: You're NOT trying to find every investor this week. You're setting up your system and doing an initial sweep. Over the next 4 weeks, you'll learn specialized tactics for each investor type and add hundreds more names to this list.

Day 1-2: Set up your free intelligence stack

  • Create a free trial Crunchbase account and save 3 searches: "Biotech + Seed Stage," "Life Sciences + Pre-seed," "Healthcare + Early Stage"

  • Set up LinkedIn search strings and save 2-3 searches: "biotech seed investor," "life sciences angel," "healthcare venture capital" (See Bonus Section for suggested search terms)

  • Create a Twitter/X list of 30-50 biotech investors to follow (search for “biotech VC”; look through top accounts, who they follow & their followers)

  • Set up your master tracking spreadsheet with columns: Investor Name, Type (Angel/VC/FO), Firm Name, Source, Website, Notes (see Bonus Section for a free template)

Day 3-4: Research comparable companies

  • Identify 8-10 companies similar to yours: same sector, stage (pre-seed to Series A), and business model (see Bonus Section for an AI Prompt to kick-start this research)

  • For each company, go to their Crunchbase profile and note all investors from their first 1-2 rounds (if recent)

  • Add all investor names to your spreadsheet with "Comparable: [Company Name]" in the Source column

Target: 80-120 investor names from comparable companies alone

Day 5-6: Initial broad sweep

  • Run your saved Crunchbase and LinkedIn searches, add 40-60 names

  • Check 1-2 recent conference sponsor/speaker/attendee lists (BIO, JPM, RESI) - add 20-30 names

  • If you have accelerator connections (JLABS, IndieBio, Y Combinator), add 20-30 investor names

Day 7: Organize and Review

  • Remove obvious duplicates from your spreadsheet

  • Add any investors from your personal network or advisor recommendations

  • Count your total: Are you at 200-300 names?

  • Review the SIFT framework one more time - you'll use it every week

Week 1 Target: A spreadsheet with 200-300 investor names and your tracking system set up

This is your foundation. Over the next 4 weeks, you'll learn specialized tactics for finding angels (Week 2), family offices (Week 3), micro-VCs (Week 4), and established VCs (Week 5). Each week will add 50-150+ names to this list using expert strategies.

By Week 5, you'll have 500-1,000+ investors. Then in Week 6, we'll FILTER and TIER them all into your final 200-300 strategic targets.

BONUS RESOURCES

You have your Week 1 action plan. Now here are three tools to help you execute it faster and more effectively.

Bonus #1: AI Mega-Prompt for comparable company research

Skip hours of manual Crunchbase work. This prompt gives you a head start in minutes.

Use it with ChatGPT, Claude, or Perplexity to research comparable companies and extract their investor lists. Includes customization instructions for your specific sector and stage.

Bonus #2: Investor tracking spreadsheet template

Your plug-and-play system to track investors through all 4 SIFT steps - from initial sourcing through final tiering.

Pre-built with 14 columns, drop-down menus, conditional formatting, and formulas to track conversion rates. Use it for the entire 30-day sprint and beyond.

Bonus #3: LinkedIn search string library + free source directory

10 copy-paste LinkedIn search strings for finding angels, VCs, and family offices - plus links to investor databases to kick-start your search.

These three resources will save you 5-10 hours this week. Download them all and start building your SOURCE list.

THAT’S A WRAP!

You now have the SIFT Fundraising System - the framework that will guide you through the next 6 weeks.

This week, your job is focused: build your foundation. Set up your tracking system and get to 200-300 initial investor names using the action plan above.

Next Sunday, we'll dive deep into Angels & Angel Groups - how to find the biotech-savvy angels who actually write $25K-$500K checks, which angel groups are worth applying to, and the specialized sourcing strategies most founders never learn.

I'd love to hear from you: How's your investor sourcing going so far? What's your biggest challenge? Hit reply and let me know - I read every response and use your feedback to shape what we cover next.

See you next Sunday with Week 2.

To your success,

- Vadim

PS: If you have someone on your team helping with fundraising or know another founder who could benefit from this intensive, forward them this email. They can sign up to join us here: [Join the Intensive]